Pdgfr-α in 1p/19q LOH oligodendrogliomas
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چکیده
منابع مشابه
Cardiac telocytes are double positive for CD34/PDGFR-α
Telocytes (TCs) are a distinct type of interstitial cells, which are featured with a small cellular body and long and thin elongations called telopodes (Tps). TCs have been widely identified in lots of tissues and organs including heart. Double staining for CD34/PDGFR-β (Platelet-derived growth factor receptor β) or CD34/Vimentin is considered to be critical for TC phenotyping. It has recently ...
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Here we present the cloning of a full-length zebrafish pdgfr-a cDNA as well as the expression of this gene during zebrafish embryogenesis. We show that zebrafish pdgfr-a mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation. Spatially restricted expression of the gene started after the onset of segmentation and is mainly localized i...
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The expression of the nuclear protein p53 in oligodendrogliomas was investigated by immunohistochemistry, using a monoclonal anti-p53 antibody (DO-7) on formalin-fixed, paraffin-embedded material in 84 histologically verified cases, and compared with the histopathological grade and survival. p53-immunoreactive cells were found in 75 per cent of the samples acquired at the first biopsy. The p53 ...
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Gliosarcomas are rare and poorly characterized malignant brain tumors that exhibit a biphasic tissue pattern with areas of gliomatous and sarcomatous differentiation. These tumors are histological variants of glioblastoma, displaying a similar genetic profile and dismal prognosis. Up-regulation of PDGFR subfamily of tyrosine kinase members, PDGFR-α and c-Kit, and their intracellular effectors R...
متن کاملPediatric and adolescent oligodendrogliomas.
PURPOSE To review the clinical and imaging findings in pediatric and adolescent intracranial pure oligodendrogliomas. METHODS The clinical, CT, and MR data in 39 surgically proved pure oligodendrogliomas were retrospectively reviewed. RESULTS The frontal or temporal lobes were involved in 32 (82%) cases. Seventy percent of the tumors were hypodense on CT, three-fourths were hypointense on T...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2004
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.20525